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doi: 10.1038/s41392-023-01580-8 11 WangSGuoQZhouLXiaX

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Why GLP-1 is the Target of Modern Weight Loss Medications The global obesity epidemic has driven intense research into therapeutic strategies for weight loss

IGF-DES Potency vs Native IGF-1 Studies using cultured cells confirmed that the biological potencies of IGF-1, IGF-2, and des-(1-3)-IGF-1 correlate inversely with their binding to IGFBP proteins in conditioned media establishing that des-(1-3)-IGF-1s enhanced in vivo and in vitro potency is a direct consequence of reduced IGFBP sequestration rather than greater intrinsic receptor affinity