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We propose that Lurcher mice suffering from early-onset olivocerebellar degeneration can be considered as a model to study the mechanisms of the components of both cerebellar motor syndrome and CCAS, with the limitation to analogous conditions (e.g., whole cerebellum affection, early loss of Purkinje cells) and of course with all the limitations of murine models of human diseases [254, 255]

Such an understanding might be important for effective programs of population health monitoring and management, a conservation priority for species like the Mongolian khulan and the plains zebra currently classified as near threatened by the International Union for Conservation of Nature

However, time consumption remains a critical bottleneck in screening combination therapy strategies