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They were then mixed with 1 mL of a 40:40:20 methanol: acetonitrile: water solution precooled to 20 C, followed by vortexing for 5 min, incubation at 20 C for 10 min, and centrifugation at 4 C and 12,000 g for 15 min

Activation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is known to be responsible for this change

Evidence ranges from early laboratory work to clinical trials depending on the use the sections below cover the actual data and sources

Ethical triage may reduce short-term surgical conversion, but it builds trust, referral quality and long-term practice reputation