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Additionally, the Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity trial demonstrated that semaglutide consistently reduced major cardiovascular event endpoints by approximately 20% compared to placebo over an approximately 3-year follow-up period in patients with overweight or obesity and cardiovascular disease (Table 1), but without diabetes [93]

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Typically, involving healthy volunteers, these trials may include patients, particularly when investigating high-risk drug candidates such as certain antitumor drugs for individuals who cannot readily benefit from existing therapies