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This study suggests a slightly increased risk of a rare but serious eye condition among people with type 2 diabetes starting GLP-1 receptor agonists compared with those starting SGLT-2 inhibitors or DPP-4 inhibitors

New in FY2027 GLP-1 Medication Coverage for the Treatment of Obesity Coverage for GLP-1 medications prescribed for the treatment of obesity only, under GIC health plans, will end at the end of Fiscal Year 2026 (FY3036), June 30, 2026 for non-Medicare plan members and on December 31, 2026 for Medicare plan members

Studies have used MT-II in direct comparison with MT-1 to characterise how cyclisation of the -MSH pharmacophore core changes receptor subtype selectivity , establishing that constraining the heptapeptide into a cyclic conformation shifts selectivity toward MC3R/MC4R relative to the linear tridecapeptide that preferentially activates MC1R

Ethics statement The studies involving humans were approved by The Third People's Hospital of Bengbu Affiliated to Bengbu Medical University