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[14] Patients typically experience sudden, severe pain in the right upper side of their abdomen or in the epigastric area (the upper, center part of the abdomen)

Importantly, AOD-9604 does not produce the side effects associated with full-length growth hormone

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The exact reasons for this have not been fully established but been suggested to be the effect of Arg-112 making ApoE4 in a tighter locked conformation than ApoE3 or ApoE2, thus hindering the lipid insertion site (Chen et al., 2021