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Functional and structural MRI studies also implicate synaptic dysfunction in mood circuitry and key networks that are associated with symptoms of depression (e.g., the default mode and central executive networks) [236,237,238,239]

Leveraging the University of California Health Data Warehouse enabled a realworld analysis of 6,871 patients with primary colon cancer and rigorous adjustment strategies to probe whether GLP1 RA exposure relates to fiveyear mortality. At the end of the study, researchers found that participants with colon cancer taking GLP-1 medications had a 15.5% mortality risk within 5 years, compared to 37.1% in participants not taking the drugs

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We repeated the replication analysis having performed mean-imputation of missing drug dose data, allowing a larger sample size of 4,855 to be analysed