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19 Gastric emptying is greatest after the first dose, so if patients choose to remain on oral contraceptives, it is recommended that a barrier method be used in the first month of treatment and during the first 4 weeks of any subsequent dose increase

Less tight

Currently, the idea seems to be that weight loss probably comes from acting on the GLP-1 or GIP receptors in the brain (as I discuss in this post), which seems unsurprising to me (people want to eat less) but apparently is a big source of controversy in the field

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