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GPX4 converts glutathione (GSH) to oxidized glutathione (GSSG) and converts lipid peroxides to the corresponding alcohols, thus preventing the occurrence of Fenton reactions and subsequently inhibiting ROS generation ( A key component of the cellular antioxidant system, System Xc is a type of amino acid anti-transporter that is substantially dispersed in a lipid bilayer and is a very selective cystine uptake system ( consists of two subunits, one is solute carrier family 7 member 11 (SLC7A11) and the other is solute carrier family 3 member 2 (SLC3A2), which enables the import of cystine from the extracellular space

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