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This suggests that a primary difference between the GF and SM protocol in terms of their individual effect on iPSCs during differentiation is the extent of metabolic rewiring and maturation in the HLCs

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"Glutathione synthesis." Biochim Biophys Acta

In this review article, we summarize the cell death subroutines in the erythroid precursors (apoptosis, necroptosis, and ferroptosis) in comparison to mature erythrocytes (eryptosis and erythronecroptosis) to highlight the consequences of organelle clearance and associated loss of multiple components of the cell death machinery upon erythrocyte maturation