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Such differences alter the dynamics of ion homeostasis, rendering species-specificities in electrophysiology, inotropic responses to stimuli, and arrhythmia susceptibility that limit the translatability of the findings (Milani-Nejad and Janssen, 2014)

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Unlike a glitazone medication like Actos (pioglitazone), which improves insulin sensitivity, GLP-1 agonists do not mainly work by directly unlocking insulin resistance the way a sensitizer doesalthough weight loss from GLP-1 therapy can indirectly improve insulin sensitivity