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Examples are MTHFR variants, which impact folate metabolism and homocysteine, FTO and MC4R, which are associated with weight regulation, CYP19A1, which is involved in aromatase and estrogen balance, ESR1 and ESR2, which are estrogen receptors, and variants in FSHR and LHCGR that alter ovarian response

For individuals considering starting or already on a weight loss journey, knowing these signs and having open communication with your care team is paramount

If you use oral contraceptives, be aware that Mounjaro may reduce their effectiveness, particularly when starting treatment or increasing doses

Limitations and challenges in thyroid disorder management Thyroid disorders, including hyperthyroidism, hypothyroidism, thyroid nodules, goiter, Hashimotos thyroiditis, and Graves disease, are subject to several limitations and challenges that pose a barrier to effective diagnosis and treatment and long-term management