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Contact your GP or trial clinician promptly if you notice: A persistent increase in resting heart rate without an obvious cause Mild but recurrent palpitations or an awareness of your heartbeat Unexplained fatigue or reduced exercise tolerance New or worsening breathlessness during everyday activities It is worth noting that some degree of heart rate elevation may be an expected pharmacological effect of retatrutide, as discussed above

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The most common observations relate less to the molecule itself than to the speed of administration

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