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Ginsenoside Rc, the main active ingredient isolated from ginseng, increases the deacetylase activity of SIRT6, thereby decreasing the level of acetylated NRF2 and increasing the stability of NRF2, which in turn attenuates hepatocellular injury and oxidative stress in alcoholic liver disease [79]

Semin Cell Dev Biol 43:2232 Wang J, Zhang M, Zhang L, Cai H, Zhou S, Zhang J, Wang Y (2010) Correlation of Nrf2, HO-1, and MRP3 in gallbladder cancer and their relationships to clinicopathologic features and survival

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doi: 10.1523/JNEUROSCI.1867-14.2014 92 QinXAkterFQinLChengJGuoMYaoSet al