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Hair mineral analysis may help identify longer-term exposure patterns, but hair treatment, external contamination and laboratory methodology affect interpretation

The most commonly reported adverse events (observed in greater than 5% of clinical trial participants) were nausea, diarrhea, vomiting, constipation, abdominal pain, dyspepsia, injection-site reactions, fatigue, hypersensitivity reactions, eructation, hair loss and gastroesophageal reflux disease

Because three receptor systems are involved, reducing the dose to manage side effects may disproportionately affect one pathway more than others, leading to unpredictable changes in the benefit profile