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Transfusion threshold generally Hgb 60 or prior thrombosis): cytoreductive therapy with hydroxyurea (first-line) or interferon-alpha (preferred in younger patients, pregnant women, or hydroxyurea intolerance)

Despite showing efficacy in ex vivo whole blood cultures, auranofin did not affect sputum culture conversion in early clinical trials [25]

Unlike newer compounds that are still emerging, GHK-CU has built a long history within scientific literature and continues to be explored in studies involving collagen production, tissue remodeling, skin quality, and cellular repair mechanisms

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