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In preclinical and clinical research models, this has translated into effects on energy expenditure, hepatic lipid metabolism, and body composition that go beyond what dual agonists alone have demonstrated

This suggests that changes in expression levels, mainly of ZnT1, are a more sensitive marker of zinc status than circulating zinc concentrations

Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver