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Based on promising preclinical data, a dual GIP/GLP-1 receptor agonist, named twincretin, has been developed and emerging evidence showed that in Phase 3 clinical trials, tirzepatide was able to induce a potent glucose-lowering and weight loss with adverse effects comparable to those of established GLP-1 receptor agonist

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Food intake, primarily the consumption of carbohydrates (sugars), stimulates the GLP-1 hormone