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The catalytic activity of the molecule appears to be involved in at least some of these actions, and several endogenous substrates have been identified, although a role for protease-independent functions related to metabolic homeostasis has also been suggested

4 Cardiovascular Risk Reduction In addition to managing blood glucose levels and promoting weight loss, GLP-1 receptor agonists have been found to reduce the risk of cardiovascular events, which is a critical consideration in diabetic patients

Strong results in appetite suppression and improved metabolic health are demonstrated by clinical studies

Individualized Glycemic Goals Both Guidelines Glycemic targets must be individualized