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Panels C and D show four week metabolic changes unique to responders in the sertraline and placebo groups respectively

Common side effects of semaglutide include: Nausea Vomiting Diarrhea Constipation Abdominal pain Indigestion (dyspepsia) Abdominal distension Decrease in appetite Belching (eructation) Gas (flatulence) Gastritis Gastroenteritis Viral gastroenteritis Gastroesophageal reflux disease (GERD) Gallstones (cholelithiasis) Headache Fatigue Dizziness Low blood glucose level (hypoglycemia) Severe hypoglycemia Diabetic retinopathy Bleeding in the vitreous, the gel-like substance within the eye (vitreous hemorrhage) Blindness Hair loss (alopecia) Antibody development Low blood pressure (hypotension) Drop in blood pressure when getting up from sitting or lying down (orthostatic hypotension) Less common side effects of semaglutide include: Discomfort and redness at the site of injection Inflammation of the pancreas (pancreatitis) Increase in amylase, the enzyme that helps digest carbohydrates Increase in serum lipase, the enzyme that breaks down fats Hemorrhoids Biliary tract disease Gallbladder disease Inflammation of the gallbladder (cholecystitis) Need for removal of gallbladder (cholecystectomy) Acute kidney injury Increased heart rate Skin rash Hives (urticaria) Bullous pemphigoid, a rare skin disorder with fluid-filled blisters Severe allergic reaction (anaphylaxis) Call your doctor immediately if you experience any of the following symptoms or serious side effects while using this drug: Serious heart symptoms include fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness