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It is important to note that PPA affects multiple systems in a complex manner and the evidence of increased PPA or other short-chain fatty-acids being involved in the pathophysiology of ASD, although compelling, is circumstantial at this stage

[221] [222] Other neurotransmitters, peptides, hormones, and enzymes Acute amphetamine administration in humans increases endogenous opioid release in several brain structures in the reward system

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