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LDN-193189 inhibe la actividad transcripcional de los receptores BMP tipo I ALK2 y ALK3 con IC50 de 5 nM y 30 nM en clulas C2C12, respectivamente, exhibiendo una selectividad 200 veces mayor para BMP frente a TGF-beta/Smad
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Gastrointestinal Histology Intestinal tissue damage was analyzed using a histologic scoring scale adapted from Chui and co-workers [62] on a scale from 0 to 5 (normal to severe) in 3 categories (mucosal injury, inflammation, hyperemia/hemorrhage) for a total score of 0 to 15 as described by Lane and co-workers [63]
Use typically relates to experimental or off-label contexts rather than approved medical treatment
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