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CAS 137525-51-0) is a synthetic 15-amino-acid peptide (sequence: GEPPPGKPADDAGLV) derived from a protective protein originally isolated from human gastric juice

10.1289/ehp.1001993 Environ

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385,387 PF1801 displays its anti-inflammatory effects by lowering levels of inflammatory mediators such as TNF, IL-6, and HMGB1, and enhances the cells antioxidant capability by upregulating molecules like Nfe2l2, Hmox1, Gclm, and Nqo1, which further improves cellular defense against oxidative stress and protects them from further damage