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Rather than serving as a first-line treatment, it is typically considered an adjunctive therapy that may complement more established approaches, such as physical therapy, exercise modification, and other evidence-based interventions

Broglio F, Benso A, Gottero C, Prodam F, Grottoli S, Tassone F, Maccario M, Casanueva FF, Dieguez C, Deghenghi R, Ghigo E, Arvat E

Some evidence indeed suggests that the presence of PEW and inflammation may justify the observed reverse association between homocysteine and clinical outcome in CKD and ESRD patients [34,35,36,37]

Navarro-SobrinoMRosellAHernndez-GuillamonMPenalbaABoadaCDomingues-MontanariSet al