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The SELECT cardiovascular outcomes trial (N=17,604), published in NEJM 2023 (DOI: 10.1056/NEJMoa2307563), demonstrated a 20% reduction in major adverse cardiovascular events (MACE) -- the composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke -- in overweight or obese adults without diabetes

Iron is particularly important for energy production and oxygen transport

Gastroparesis In rare cases, semaglutide has been associated with gastroparesis severe slowing of stomach emptying beyond the expected therapeutic effect

Machine learning models revealed that self-reported sleep quality could detect all depression symptoms measured using the Patient Health Questionnaire-14, whereas physiological sleep measures detected sleeping too much and low libido