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Serious safety concerns for tirzepatide include: Boxed warning for thyroid C-cell tumors (contraindicated in patients with personal/family history of MTC or MEN2) Risk of pancreatitis Gallbladder disease Acute kidney injury from dehydration Hypoglycemia (when used with insulin or sulfonylureas) Serious safety concerns for orlistat include: Rare cases of severe liver injury Risk of oxalate nephropathy and kidney stones Nutritional considerations also warrant attention

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(iii) the number of energy evaluations: 2.5 million (2.0 clustered tolerance)

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