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2024 Meta-Analysis Indicates That GLP-1RAs Reduce Adverse CV Events A 2024 Meta-analysis of 13 multiple cardiovascular outcome trials has documented that GLP1-RA therapy significantly reduces the risk of major adverse cardiovascular events (MACEs), all-cause mortality, CV mortality, stroke, risk for coronary revascularization, and composite adverse kidney outcomes in both sexes, regardless of a patient's history of cardiovascular disease, BMI or eGFR (Rivera et al, 2024)

For some people, skin on the upper leg is tough, thick, and fatty, which may inhibit the physical insertion of the pen

Judith Korner, professor of medicine in the Division of Endocrinology at New York Presbyterian/ Columbia University Irving Medical Center in New York

Around one-third of patients lose 20% or more of their starting weight during this window