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In the PIONEER clinical trials, mean HbA1c reductions ranged from approximately 0.7% to 1.3%, depending on the dose and baseline characteristics

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A supplement providing 18 mg hyaluronic acid per 10 kg body weight per day, along with 500 mg glucosamine hydrochloride, 300 mg chondroitin sulfate, 4 mg non-hydrolyzed type II collagen, and 70 mg of an anti-inflammatory herbal combination per 10 kg body weight per day, improved subjective pain measures and clinical status in dogs with osteoarthritis after 60 days of treatment