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Systemic complications include hypersensitivity reactions to the substances administered, hypertransaminasemia, demyelinating neuropathy, and ischemic colitis.2 Mild pain, hematomas, and erythema, and moderate pruritus and edema are often observed locally, at the sites of injection, and tend to resolve untreated within a few days

& Hamer, G

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From a life-sciences and manufacturing vantage point, the question is not Melanotan 1 vs 2: which is safe? but Is any unregulated systemic tanning peptide justifiable when weighed against the reality of skin cancer and the uncertainties of underground peptide production? Melanotan I and II are clever pieces of peptide engineering that illustrate both the promise and peril of pharmacological tanning