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Short-acting agents like exenatide immediate-release (Byetta) and lixisenatide (Adlyxin) do not carry this warning

Annals of Clinical Biochemistry, 56 (4), 466471

Patients experiencing significant symptoms may wish to schedule botulinum toxin treatment during periods of better symptom control

The GLP-1R in the brain is the same as the GLP-1R in the periphery, although the source of GLP-1 that binds to these receptors differs, Rinaman explained