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Schafmayer C, Hartleb J, Tepel J, et al

Although the number of beige adipocytes did not increase, they displayed a more thermogenic phenotype characterized by smaller LDs, elevated expression of uncoupling protein 1 ( UCP1 ) and HSL , and enhanced glucose utilization, all features consistent with increased mitochondrial uncoupling and browning

These compounds offer distinct advantages over their peptide-based counterparts, including oral bioavailability, improved patient adherence, and the potential for broader therapeutic applications

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