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Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice

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This activation upregulates both the expression and enzymatic activity of MMP-9, leading to degradation of critical structural components in the basement membrane of the blood-brain barrierparticularly type IV collagenthereby compromising barrier integrity and increasing permeability (105, 106)

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