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For example, studies on semaglutide 2.4 mg daily reveal an average 8% weight loss in individuals with diabetes over 60 weeks, while those without diabetes see closer to 11%

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By aligning key protocol components and analytic frameworks with those of SUSTAIN-6 and SURPASS-CVOT, we produced self-critical evidence that allowed us to directly benchmark results against reference trials to inform subsequent analyses in expanded populations