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In the vascular system, catechol estrogens regulate nitric oxide production and have other modulatory functions ( 3 Estrogen signaling in skin Estrogen actions are mediated through canonical nuclear and/or non-canonical membrane-initiated steroid signaling ( ++ , cAMP, or protein kinase cascades) that regulate downstream transcription and epigenetic factors (Figure 3), although this has not been directly investigated, and data regarding the role and expression of ER in skin cells and during wound healing are inconsistent (Verdier-Sevrain et al., 2004)

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