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Across 2,783 participants, GLP-1RAs were associated with: - Higher rates of MASH resolution without worsening fibrosis - Reduced liver fat and improved ALT, AST, and GGT levels - Significant decreases in body weight, BMI, waist circumference, HbA1c, and triglycerides While gastrointestinal side effects (nausea, vomiting, diarrhea) were more common, the overall benefit profile was substantial
Multiple types of dietary patterns in the management of T2D-associated metabolic dysregulation The manifestation and heterogeneity of the prevalence of T2D are influenced by a combination of factors, including diverse ancestry, varied dietary patterns, and heterogeneous edible oil consumption across different agroclimatic conditions
Efficacy and safety of once-weekly GLP-1 receptor agonist albiglutide (HARMONY 2): 52 week primary endpoint results from a randomised, placebo-controlled trial in patients with type 2 diabetes mellitus inadequately controlled with diet and exercise