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SAGE Journals+1 Safety (preclinical): multi-species toxicology work (mice, rats, rabbits, dogs) reported good tolerability at tested doses

[121] Age is also a contributing factor: elderly individuals are often achlorhydric due to reduced parietal cell function in the stomach, increasing their risk of vitamin B 12 deficiency

It also promotes the production of other healing proteins in the body

A randomised double-blind placebo-controlled study evaluating eccentric exercises and PRP or saline injection showed no difference in improvement in pain and activity at six months, and a recent meta-analysis concluded that although there may be benefit in using PRP to increase the healing strength in tendo Achilles repair following acute rupture, there was no evidence of any benefit in using PRP in the treatment of Achilles tendinopathy