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While clinical trials concluded that GLP-1 helps patients lose weight as a stand-alone therapy, combining it with lifestyle changes produces far more dramatic results

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A taper reverses this ladder over a similar 20-to-24-week window: Weeks 1 to 4: reduce to 12.5 mg weekly Weeks 5 to 8: reduce to 10 mg weekly Weeks 9 to 12: reduce to 7.5 mg weekly Weeks 13 to 16: reduce to 5 mg weekly Weeks 17 to 20: reduce to 2.5 mg weekly Week 21: discontinue, or evaluate ongoing need at 2.5 mg The SURMOUNT-3 trial (N=579) showed that patients who completed an intensive lifestyle intervention before starting tirzepatide lost an additional 18.4% on-drug [9]