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Inhibition of peroxynitrite-induced nitration of tyrosine by glutathione in the presence of carbon dioxide through both radical repair and peroxynitrate formation

The proportion of ischemic stroke patients receiving IVT increased from 3.38% in 2020 to 13.0% in 2024, while the rate of patients receiving mechanical thrombectomy rose from 0.38% in 2020 to 6% in 2024

Intravenous administration of lipoic acid at doses of 600 mg/day for three weeks (112) and oral lipoic acid at doses as high as 1,800 mg/day for six months (113) and 1,200 mg/day for two years (76) did not result in serious adverse effects when used to treat diabetic peripheral neuropathy