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Although studies determining the structure of GLP-1 bound to the N-terminal, extracellular domain of the receptor showed that the residues 13-33 of the GLP-1 peptide analogs form a helical structure (PDB ID 3iol, Underwood et al., 2010), recent EM structures of the whole receptor bound to the GLP-1 protein (PDB ID 6x18, Zhang et al., 2020) shows that the entire GLP-1 peptide forms a long helix as it binds to its receptor

The most common side effects are gastrointestinal, including nausea, diarrhoea, vomiting, constipation, and reduced appetite

Recent clinical trials have also demonstrated that Ozempic and Wegovy are highly efficacious in preventing adverse cardiovascular events like heart attacks

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