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The acidic tumor microenvironment drives a stem-like phenotype in melanoma cells

In obese adults, OXM was found to be a dual agonist for the glucagon (GCG) receptor (GCGR) and the GLP-1 receptor (GLP-1R), suppressing hunger, increasing energy expenditure, and causing weight reduction [22]

Tumor necrosis factor- is highly related to muscle wasting conditions such as cancer cachexia as well as AIDS and other muscle inflammatory conditions