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The half-life of this hormone is only approximately two minutes, with cleavage by DPP-4 enzymes occurring at the second residue of incretins, resulting in only 1015% of secreted GLP-1 reaching the systemic circulation [26]

The gut adapts to a given GLP-1 exposure level over time, and the constipation signal often reflects a mismatch between current receptor activation and the gut's adaptive capacity

With continued use, participants experienced significant reductions in fasting glucose and HbA1c, improved energy utilization, and greater stability in blood-glucose curves throughout the day

Patients should avoid transferring the tablets to clear containers or pill organizers for extended periods, as this could expose the medication to light and potentially reduce its potency