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Legitimate access is limited to participation in authorised clinical trials or, if granted, MHRA early access mechanisms such as the Early Access to Medicines Scheme (EAMS) neither of which has been announced for retatrutide at this time

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The pathophysiologic mechanisms underpinning S-AKI are complex, and recent studies have shown that acute tubular necrosis, oxidative stress (7), mitochondrial dysfunction, inflammatory responses (8), microvascular dysfunction (9), and ischemia are involved (Figure 1)

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