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GLP-1RAs and Other Mechanisms According to the Global Burden of Disease 2019 data report, 68 although age-standardized mortality from chronic respiratory diseases has shown a gradual decline globally from 1990 to 2019, COPD still has the highest age-standardized mortality rate of all chronic respiratory diseases and COPD is also the largest burden of death from chronic respiratory diseases, a situation that may remain difficult to improve in the future

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