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Gastrointestinal effects lead: nausea, diarrhea, constipation, and vomiting, dose-dependent and clustered during escalation, mostly mild. Tirzepatide also produces a modest chronic heart-rate rise with a larger escalation-phase peak. Oral-contraceptive absorption can fall after starting and after each increase, so use backup or non-oral contraception for 4 weeks each time. What is known about concurrent metformin and tirzepatide use

Causes for high blood pressure include: Diabetes Being overweight or obese Smoking Not getting enough regular physical activity Unhealthy diets, including high amounts of sodium and alcohol Talk to your provider about how you can lower your blood pressure to help avoid heart disease and stroke

Factors such as eating habits, meal composition, and the rate of dose titration can significantly influence the severity of gastrointestinal side effects

When to Contact Your Healthcare Provider About a Missed Dose If you miss a dose but remember within a few days, you typically don't need to contact your providersimply take the dose when you remember and resume your schedule