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Intravenous infusion of GLP-1 for 48 h in healthy human subjects increased muscle sympathetic nerve activity but had no effect on BP, norepinephrine plasma concentration, or the sympathetic/parasympathetic balance as estimated by the HR variability, suggesting that the increase in sympathetic drive is at least partially compensated by an increase in the parasympathetic activity [53]

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The following are the more likely side effects experienced with peptides: Injection site discomfort Changes in blood pressure, either increases or decreases depending on the peptide Fatigue and dizziness Hot or cold feelings Kidney and liver toxicity Potential toxicity to fetuses Abnormal heart rhythms Increased feelings of hunger Joint pain Tingling or numbness Water retention (this is a sign of overdose) Weight gain or loss Peptides with anabolic effects should not be considered for those with history or at risk of cancer Most side effects are localized and self-limiting