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4.7 Appetite and satiety Appetite and weight regulation are controlled by the central nervous system in a fairly complex manner, with the human brain playing a central role in integrating internal and external inputs and regulating energy homeostasis (Farr et al., 2016a)

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Correcting this imbalance through targeted inhibition of pro-inflammatory pathways or supplementation of regulatory metabolites can reset immunological homeostasis, underscoring the translational potential of metabolic checkpoint therapy in autoimmunity

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