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GIP, the second target activated by tirzepatide and Retatrutide, adds complementary effects on insulin secretion and fat metabolism while also influencing reward pathways through distinct mechanisms

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Biosimilar entrants compress price points for mature insulins and DPP-4 inhibitors, pressuring innovators to pivot toward differentiated GLP-1 and dual-agonist pipelines

We report for the first time the results of the use of combination therapy with a glucagon-like peptide-1 receptor agonist and a sodium-glucose cotransporter 2 inhibitor for the treatment of diabetes in the context of type A IR syndrome