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These studies can also help to establish health care resource utilisation benefits, and provide cost implications for the use of SGLT2 inhibitor and GLP-1 RA therapies in everyday practice [132]

The extrinsic pathway is initiated by the binding of proapoptotic ligands to death receptors on the cell surface, leading to the formation of the death-inducing signaling complex (DISC) and the activation of caspases (Qiao et al., 2024)