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The formation of 5-methylTHF depends on N 5,10 -methylenetetrahydrofolate reductase (MTHFR), which catalyzes the reduction of N 5,10 -methylenetetrahydrofolate (5, 10-methyleneTHF) (Fig

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Key findings: No increased thyroid cancer risk versus any comparator Consistent findings across multiple subgroups Multiple comparator groups reduce artifact risk JAMA Otolaryngology Analysis High-profile paper directly addressing how detection bias and healthcare utilization create apparent diagnosis increases that aren't causal

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