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Palaniappan K, et al

Managing GI Side Effects in Advanced CKD GLP1 RAs commonly cause gastrointestinal issues such as nausea and vomiting, especially early in treatment

However, this reduced IGFBP binding comes with a pharmacokinetic trade-off: while native IGF-1 circulates with a half-life of 12-15 hours due to IGFBP stabilization, IGF-1 LR3 has a significantly shorter half-life of approximately 20-30 hours

Abstract Cardiovascular and renal complications remain leading causes of morbidity and mortality among individuals with type 2 diabetes mellitus (T2DM)